Saxenda - The Medical Center for Obesity Treatment

Q: What is the recommended dosage?

At the start of treatment, your doctor will determine your weekly Saxenda dosage, which typically increases gradually based on the rate of weight loss until reaching the optimal dose. Patients generally remain at this optimal dosage until completion of their treatment.

Q: When should the medication be taken?

Saxenda can be injected at any time of the day, but it's best to administer it at the same time each day. The medication can be injected independently of meal times.

Q: What are the common side effects of Saxenda?

As with any medication, treatment with Saxenda may cause side effects, although most of them are mild and typically resolve within a few days to weeks. Common side effects include gastrointestinal symptoms, such as nausea, vomiting, diarrhea or constipation, as well as hypoglycemia (a sharp drop in blood sugar levels). Other possible side effects include digestive discomfort (such as gas, hiccups, and belching), heartburn, stomach pain or inflammation, changes in taste, dry mouth, dizziness, increased heart rate, fatigue, sleep disturbances, and gallstones. It’s important to remember that your healthcare provider, especially one specialized in obesity treatment, can offer advice on how to significantly reduce or even prevent these side effects. Real-time dynamic adjustments to your medication - including dosage changes and careful monitoring when combined with other medications - can greatly improve patient adherence and significantly reduce dropout rates from treatment.

Q: What are the rare side effects of Saxenda?

Rare side effects may include severe allergic reactions (anaphylaxis), reduced kidney function or acute kidney failure, and liver or pancreas damage. (It's important to note that obesity itself triples the risk of pancreatitis.)

Q: Who should avoid treatment with Saxenda, and who should exercise caution during treatment?

Saxenda is not recommended for individuals suffering from severe heart failure, serious gastrointestinal conditions that cause delayed stomach emptying (gastroparesis), or inflammatory bowel diseases. Additionally, the medication may increase the risk of thyroid issues, including thyroid malignancy. Caution is also advised in situations that increase the risk of pancreatitis. Patients taking Coumadin may require regular monitoring of blood clotting parameters. Patients using glimepiride or glibenclamide may need dosage adjustments by their doctor to prevent excessively low blood sugar levels.

Q: How much does Saxenda cost, and is it included in the national healthcare basket?

The price of Saxenda (package of 5 x 3 ml) is ₪1,122. Saxenda is not included in Israel's national healthcare basket, but it may be covered by internal healthcare packages offered by certain health maintenance organizations (HMOs), in which case it is available at a discounted price for their members. Additionally, Saxenda may be purchased at varying discounts through supplementary insurance plans.

Saxenda - An Innovative Medication for Obesity Treatment

Saxenda is used for weight loss and prescribed as part of a personalized treatment plan that includes medical supervision and dietary adjustments. Saxenda works by reducing appetite and increasing feelings of fullness after meals. One of its significant advantages is that it is suitable for adults as well as adolescents aged 12 and older, with a BMI of 30 or higher, or a BMI of 27 or higher accompanied by an additional obesity-related risk factor.

Eligibility Criteria for Receiving the Medication

Age 12 and older.
BMI (Body Mass Index) of 30 or higher, classified as severe obesity.
BMI (Body Mass Index) of 27 or higher, classified as overweight, provided there is at least one additional obesity-related risk factor such as diabetes, high blood pressure, elevated blood lipid levels, etc.

To Check Eligibility for Medication-Based Treatment (BMI Calculator)

Medication Name

Saxenda®

Method of Administration

Solution for subcutaneous injection (3 ml) in a ready-to-use pen.

Active Ingredient in the Medication

Liraglutide

Manufacturer of the Medication

Novo Nordisk

Medication Manufacturing Policy

The medication is manufactured in Denmark.

When Was the Medication Approved for Use?

The medication was approved for use in the United States in 2014 and has been approved for use in Israel since 2016.

Is a Prescription Required?

Yes, a doctor's prescription is required to take this medication.

What Is the Medication Intended For?

Saxenda is a medication prescribed for weight loss.

How Is the Medication Used?

Saxenda is prescribed as part of a personalized treatment plan, which includes dietary changes and physical activity in addition to medication, as needed.

כיצד משתמשים בתרופה

It's Not Just About Willpower. It's About Science!

Studies Show:

Patients taking Saxenda experienced an average weight reduction of approximately 10% of their body weight.

% 0

Patients taking Saxenda lost about 5% or more of their body weight.

% 0

The new weight was maintained for at least two years.

How does Saxenda work in the body?

Saxenda is a medication based on a molecule similar in structure and function to a natural human hormone called GLP-1, which is released whenever we eat. This hormone decreases appetite and enhances feelings of fullness after meals. The active ingredient in Saxenda mimics the action of GLP-1 by interacting with nerve cells (neurons) in the brain responsible for regulating appetite, while also slowing down the emptying of food from the stomach. Thus, Saxenda belongs to a class of medications known as “Incretin Mimetics.”

In fact, Saxenda contains the same active substance as the medication Victoza, used in diabetes treatment. Victoza helps regulate blood sugar by increasing insulin secretion from pancreatic beta cells in response to eating food. The key difference between these two medications lies in their prescribed dosages. It was discovered that starting from a certain dosage, this active ingredient not only helps manage blood sugar levels but also contributes to weight loss.

What is the research basis for the effectiveness of Saxenda?

Saxenda’s efficacy and safety for the treatment of overweight and obesity have been proven through four placebo-controlled clinical studies, involving a total of over 5,000 participants. The largest study examining the effectiveness and safety of Saxenda included 3,731 participants and lasted for 56 weeks \[1].

At the end of this study period, Saxenda contributed to an average body weight reduction of 8%, compared to just 2.6% in participants who took a placebo and relied solely on dietary changes and physical activity. Additionally, 63.5% of participants treated with Saxenda lost 5% or more of their body weight, compared to only 26.6% in the placebo group.

Furthermore, 33% of Saxenda users achieved a weight loss of over 10%, compared to just 10% of those receiving the placebo.

In another placebo-controlled clinical trial \[2], involving 846 participants with overweight or obesity and type 2 diabetes, Saxenda demonstrated effectiveness and safety in promoting weight loss when combined with diet and exercise. After 56 weeks, 54.3% of participants taking Saxenda lost 5% or more of their body weight, compared to only 21.4% in the placebo group. Furthermore, 25.2% of Saxenda users achieved a weight reduction of more than 10%, while only 6.7% of placebo users reached this threshold.

What about diabetes management? Saxenda was found not only effective for weight loss but also in reducing the risk of developing diabetes. This was demonstrated in a 56-week clinical study involving participants with pre-diabetes and a BMI of 30 or higher, or a BMI of 27 or higher along with weight-related health conditions (such as hypertension) \[3].

Studies have also shown that the therapeutic effectiveness of Saxenda lasts for at least three years, helping patients maintain their weight loss results over time. As a result, the FDA has approved Saxenda for long-term treatment.

The Multidisciplinary Approach to Obesity Treatment

The most effective method for weight loss through medication is a personalized treatment plan, supported and monitored by a multidisciplinary team of experts.

Various clinical studies \[4,5] conducted in recent years have shown that the most successful approach to weight loss combines individually tailored medications at adjustable dosages, including medication combinations, with medical supervision and ongoing nutritional follow-up by a clinical dietitian within a structured treatment framework. This process significantly improves patient adherence and supports long-term weight maintenance.

The Obesity Treatment Center offers a comprehensive multidisciplinary weight loss program combined with medication-based treatment. This program includes:

Combined Treatment

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To enhance the effectiveness of treatment and achieve maximum results in minimal time, Dr. Raz may combine the medication with additional weight-loss drugs that operate through different mechanisms and adjust dosages based on treatment needs. The Obesity Treatment Center offers innovative and advanced medications at the forefront of weight loss science, and we specialize in creating customized treatment protocols that utilize drug combinations to deliver fast, safe results.

Personal Guidance

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Demonstration and guidance on how to administer the weight-loss medication and how to gradually increase the dosage as needed to achieve maximum results in minimal time.

Diagnosis

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The diagnostic process includes a comprehensive physical examination, measurement of body circumference, weight, metabolic rate, water balance, and body fat and muscle mass percentages. These assessments are performed using advanced technology based on bioelectrical impedance. Each patient undergoes a thorough questionnaire to assess their physical and emotional condition, medical history, underlying health issues, and ongoing medication use, in order to create a fully personalized treatment plan.

Personal Follow-Up

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Dr. Raz maintains personal contact with each patient throughout all treatment stages. Patients attend monthly consultation sessions for tailored treatment adjustments. The Obesity Treatment Center offers 24/7 availability for immediate support. Patients are encouraged to directly contact the center at any time with questions, concerns, or side effects. Immediate responses and guidance are provided without delay. Patients can also monitor their personal treatment progress using a dedicated app. The app provides continuous real-time updates regarding each patient's individual status.

Reducing Side Effects

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Any medication may cause side effects alongside its therapeutic benefits. Many patients have previously tried medication-based weight loss treatments but discontinued due to unmanaged side effects. At the Obesity Treatment Center, we emphasize precise medication dosing tailored to each patient, alongside nutritional adjustments and ongoing monitoring. Clinical experience shows that dynamically adjusting medication doses as needed and ensuring proper drug combinations can prevent or minimize side effects. Additionally, the center provides 24/7 availability to promptly address any side effects in real-time.

Continuity of Care

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As with any medical treatment, weight loss through medication must be carried out consistently as part of a routine. One of the main challenges in this area is patient adherence and their ability to persist with treatment, including medication-based weight loss. Close follow-up at the Obesity Treatment Center, combined with personalized support, side-effect monitoring, and emotional guidance, greatly increases each patient's adherence and significantly reduces dropout rates.

Personally Guided Nutritional Program

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Patients at the center receive ongoing guidance, treatment, and support from a clinical dietitian, with a personalized nutritional plan that addresses all aspects of the patient’s lifestyle, without restricting favorite foods. Moreover, dietary treatment isn't just about a meal plan; at our center, we emphasize not only what to eat but also how to eat. We provide patients with practical behavioral tools to optimally adjust to their medication treatment, helping them reconnect with their natural hunger and fullness signals. This approach keeps the body satisfied and calm throughout the process, enabling significant and lasting weight loss.

Lifestyle Habits

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Many patients come to us frustrated and discouraged from previous failed attempts. Some arrive feeling hopeless, doubting their ability to maintain results, no matter how successful the treatment was. That's exactly where we step in. We focus on providing practical lifestyle tools to help you maintain a healthy weight, even after completing treatment at the clinic. Treatment at the Obesity Medical Center is your first step toward a healthier life and lasting weight management.

טבלת קליקים וויגובי - כל המינונים

Wegovy 0.25mg

Wegovy 0.25mg
מינון	קליק
0.006	1
0.013	2
0.02	3
0.027	4
0.033	5
0.04	6
0.047	7
0.054	8
0.06	9
0.067	10
0.074	11
0.081	12
0.087	13
0.094	14
0.1	15
0.108	16
0.114	17
0.121	18
0.128	19
0.135	20
0.141	21
0.148	22
0.155	23
0.168	24
0.168	25
0.175	26
0.182	27
0.189	28
0.195	29
0.202	30
0.209	31
0.216	32
0.222	33
0.229	34
0.236	35
0.243	36
0.25	37

Wegovy 0.5mg

Wegovy 0.5mg
מינון	קליק
0.0135	1
0.027	2
0.0405	3
0.0541	4
0.0676	5
0.0811	6
0.0946	7
0.1081	8
0.1216	9
0.1351	10
0.1486	11
0.1622	12
0.1757	13
0.1892	14
0.2027	15
0.2162	16
0.2297	17
0.2432	18
0.2568	19
0.2703	20
0.2838	21
0.2973	22
0.3108	23
0.3243	24
0.3378	25
0.3514	26
0.3649	27
0.3784	28
0.391	29
0.405	30
0.418	31
0.432	32
0.445	33
0.459	34
0.472	35
0.486	36
0.5	37

Wegovy 1mg

Wegovy 1mg
מינון	קליק
0.013	1
0.026	2
0.04	3
0.053	4
0.066	5
0.08	6
0.093	7
0.106	8
0.12	9
0.133	10
0.146	11
0.16	12
0.173	13
0.186	14
0.2	15
0.213	16
0.226	17
0.24	18
0.253	19
0.266	20
0.28	21
0.293	22
0.306	23
0.32	24
0.333	25
0.346	26
0.36	27
0.373	28
0.386	29
0.4	30
0.413	31
0.426	32
0.44	33
0.453	34
0.466	35
0.48	36
0.493	37
0.506	38
0.52	39
0.533	40
0.546	41
0.56	42
0.573	43
0.586	44
0.6	45
0.613	46
0.626	47
0.64	48
0.653	49
0.666	50
0.693	51
0.693	52
0.706	53
0.72	54
0.733	55
0.746	56
0.76	57
0.773	58
0.786	59
0.8	60
0.813	61
0.826	62
0.84	63
0.853	64
0.866	65
0.88	66
0.893	67
0.906	68
0.92	69
0.933	70
0.946	71
0.96	72
0.973	73
0.986	74
1	75

Wegovy 1.7mg

Wegovy 1.7mg
מינון	קליק
0.022	1
0.045	2
0.068	3
0.09	4
0.113	5
0.136	6
0.158	7
0.181	8
0.204	9
0.226	10
0.249	11
0.272	12
0.294	13
0.317	14
0.34	15
0.362	16
0.385	17
0.408	18
0.43	19
0.453	20
0.476	21
0.498	22
0.521	23
0.544	24
0.566	25
0.589	26
0.612	27
0.634	28
0.657	29
0.68	30
0.702	31
0.725	32
0.748	33
0.77	34
0.793	35
0.816	36
0.838	37
0.861	38
0.884	39
0.906	40
0.929	41
0.952	42
0.974	43
0.997	44
1.02	45
1.04	46
1.065	47
1.088	48
1.11	49
1.133	50
1.156	51
1.178	52
1.201	53
1.224	54
1.246	55
1.269	56
1.292	57
1.314	58
1.337	59
1.36	60
1.382	61
1.405	62
1.428	63
1.45	64
1.473	65
1.496	66
1.518	67
1.541	68
1.564	69
1.586	70
1.609	71
1.632	72
1.654	73
1.677	74
1.7	75

Wegovy 2.4mg

Wegovy 2.4mg
מינון	קליק
0.032	1
0.064	2
0.096	3
0.128	4
0.16	5
0.192	6
0.224	7
0.256	8
0.288	9
0.32	10
0.352	11
0.384	12
0.416	13
0.448	14
0.48	15
0.512	16
0.544	17
0.576	18
0.608	19
0.64	20
0.672	21
0.704	22
0.736	23
0.768	24
0.8	25
0.832	26
0.864	27
0.896	28
0.928	29
0.96	30
0.992	31
1.024	32
1.056	33
1.088	34
1.12	35
1.152	36
1.184	37
1.216	38
1.248	39
1.28	40
1.312	41
1.344	42
1.376	43
1.408	44
1.44	45
1.472	46
1.504	47
1.536	48
1.568	49
1.6	50
1.632	51
1.664	52
1.696	53
1.728	54
1.76	55
1.792	56
1.824	57
1.856	58
1.888	59
1.92	60
1.952	61
1.984	62
2.016	63
2.048	64
2.08	65
2.112	66
2.144	67
2.176	68
2.208	69
2.24	70
2.272	71
2.304	72
2.336	73
2.368	74
2.4	75

מונג'רו / מאונג'רו טבלת קליקים - מינונים

Mounjaro 2.5mg

מונג’רו 2.5mg
מינון	קליק
0.0417	1
0.0833	2
0.125	3
0.1667	4
0.2083	5
0.25	6
0.2917	7
0.3333	8
0.375	9
0.4167	10
0.5	12
0.625	15
0.75	18
0.8333	20
1	24
1.25	30
1.5	36
1.6667	40
2	48
2.5	60

Mounjaro 5mg

מונג’רו 5mg
קליק	מינון
1	0.0833
2	0.1667
3	0.25
4	0.3333
5	0.4167
6	0.5
7	0.5833
8	0.6667
9	0.75
10	0.8333
12	1
15	1.25
18	1.5
20	1.6667
24	2
30	2.5
36	3
40	3.3333
48	4
60	5

Mounjaro 15mg

מונג’רו 15mg
קליק	מינון
1	0.25
2	0.5
3	0.75
4	1
5	1.25
6	1.5
7	1.75
8	2
9	2.25
10	2.5
12	3
15	3.75
18	4.5
20	5
24	6
30	7.5
36	9
40	10
48	12
60	15

Mounjaro 7.5mg

מונג’רו 7.5mg
קליק	מינון
1	0.125
2	0.25
3	0.375
4	0.5
5	0.625
6	0.75
7	0.875
8	1
9	1.125
10	1.25
12	1.5
15	1.875
18	2.25
20	2.5
24	3
30	3.75
36	4.5
40	5
48	6
60	7.5

Mounjaro 10mg

מונג’רו 10mg
קליק	מינון
1	0.1667
2	0.3333
3	0.5
4	0.6667
5	0.8333
6	1
7	1.1667
8	1.3333
9	1.5
10	1.6667
12	2
15	2.5
18	3
20	3.3333
24	4
30	5
36	6
40	6.6667
48	8
60	10

Mounjaro 12.5mg

מונג’רו 12.5mg
קליק	מינון
1	0.2083
2	0.4167
3	0.625
4	0.8333
5	1.0417
6	1.25
7	1.4583
8	1.6667
9	1.875
10	2.0833
12	2.5
15	3.125
18	3.75
20	4.1667
24	5
30	6.25
36	7.5
40	8.3333
48	10
60	12.5

Frequently Asked Questions (FAQ)

What is the recommended dosage?

When should the medication be taken?

What are the common side effects of Saxenda?

What are the rare side effects of Saxenda?

Who should avoid treatment with Saxenda, and who should exercise caution during treatment?

How much does Saxenda cost, and is it included in the national healthcare basket?

The information on this page does not replace medical consultation or serve as a basis for diagnosis. For detailed information regarding the medication, please refer to the patient information leaflet as approved by the Ministry of Health. For any additional questions, please consult your healthcare provider or pharmacist.