qsymia

Q: What is the recommended dosage?

At the beginning of treatment, your doctor will determine your weekly dosage of Qsymia.

Q: When should the medication be taken?

Take one Qsymia capsule daily, preferably at the same time each day, and on an empty stomach.

Q: What are the common side effects of Qsymia?

As with any medication, treatment with Qsymia may cause side effects; however, most are mild and typically subside within days to weeks. Common side effects include tingling sensations, dizziness, changes in taste, and insomnia. It's important to remember that your healthcare provider, especially if specialized in obesity management, can provide guidance on how to significantly reduce or even prevent these side effects. Real-time adjustments to your medication, including dosage changes and careful monitoring when combined with other medications, can improve treatment adherence and significantly decrease dropout rates among patients.

Q: What are the rare side effects of Qsymia?

Rare side effects may include increased resting heart rate, difficulties concentrating, vision changes, the onset of depression or other mood disorders, and occasionally suicidal thoughts or behaviors.

Q: Who should avoid treatment with Qsymia, and who should exercise caution during treatment?

Qsymia should not be used by individuals with glaucoma, hyperthyroidism, or by patients who have experienced a heart attack or stroke within the past 6 months before starting the medication. Additionally, it must not be used by individuals currently taking antidepressants from the MAO inhibitor group. Pregnant women cannot initiate treatment with Qsymia due to risks of birth defects. Women of childbearing age must avoid becoming pregnant during treatment with Qsymia. For this reason, monthly pregnancy tests via blood samples are required throughout the entire treatment period to ensure they are not pregnant.

Q: How much does Qsymia cost, and is it covered by the national healthcare system?

The medication has not yet been approved for use in Israel. Once approved, pricing policies and coverage of Qsymia will be determined by health maintenance organizations (HMOs) and various insurance providers.

Qsymia - Innovative Medication for Weight Loss

Qsymia is used in the United States for weight loss by reducing appetite and controlling cravings for sugars and carbohydrates. Studies have demonstrated that individuals taking Qsymia achieved at least 5% weight loss within 8 weeks, along with significant improvements in metabolic markers such as blood sugar and lipid levels. Qsymia is not registered in Israel and is available through special authorization for weight management.

Eligibility Criteria for Receiving the Medication

Age 18 or older.
BMI (Body Mass Index) of 30 or higher, defined as severe obesity.
BMI (Body Mass Index) of 27 or higher, defined as overweight, provided there is at least one additional obesity-related risk factor, such as diabetes, high blood pressure, elevated blood lipid levels, etc.

To Check Eligibility for Medication-Based Treatment (BMI Calculator)

Medication Name

Qsymia®

Method of Administration

Qsymia is administered in capsule form, taken once daily on an empty stomach.

Active Ingredient in the Medication

Qsymia contains two active ingredients: Phentermine and Topiramate.

Manufacturer of the Medication

Vivus

Medication Manufacturing Policy

The medication is manufactured in the United States.

When Was the Medication Approved for Use?

Qsymia has been approved for use in the United States since 2012 but is not yet approved in Israel (information accurate as of 2022).

Is a Prescription Required?

Yes, taking the medication requires a doctor's prescription.

What Is the Medication Intended For?

Qsymia is a medication prescribed for weight loss, subject to the submission of a 29C form.

How Is the Medication Used?

Qsymia is prescribed as part of a personalized treatment plan, which includes not only medication but also dietary adjustments and physical activity tailored to your specific needs.

כיצד משתמשים בתרופה

It's Not Just About Willpower. It's About Science!

Studies Show:

Patients taking Qsymia experienced a weight loss of at least 10% of their body weight after approximately one year.

% 0

Patients taking Qsymia experienced a noticeable reduction in body weight within just 8 weeks.

% 0

Reduced risk of developing type 2 diabetes among overweight individuals who lose 5% of their body weight.

% 0

What is the mechanism of action of Qsymia?

Qsymia contains a combination of two medications: Phentermine and Topiramate, both of which are approved by the U.S. Food and Drug Administration (FDA).

Phentermine acts similarly to amphetamines by stimulating the sympathetic nervous system. It promotes the release of the neurotransmitter norepinephrine in the brain, thereby increasing the level of the hormone leptin. Leptin, in turn, suppresses appetite and enhances feelings of fullness after meals.

Topiramate, on the other hand, was initially developed as an anti-seizure medication, but researchers later discovered that one of its additional effects is appetite suppression and increased feelings of fullness. Although the exact mechanism by which topiramate contributes to weight loss is still not completely understood, studies have shown it influences the neurotransmitter GABA, which plays a role in regulating appetite and feelings of fullness after meals. Additionally, topiramate inhibits enzymes known as carbonic anhydrase, thereby slowing down processes responsible for producing fats in the body, such as triglycerides.

The uniqueness of Qsymia lies in combining two active ingredients that operate through different mechanisms, as well as its extended-release formulation, typically allowing for just one capsule to be taken per day.

What are the results of studies examining Qsymia?

Two large, long-term clinical studies (involving 3,754 participants, lasting 56 weeks) examined the effectiveness and safety of Qsymia. All participants had a BMI of 27 or higher, and the medication was combined with diet and exercise.

In the first study \[1], involving 1,267 men and women with a BMI ranging from 35 to 79, participants taking the highest dose of Qsymia lost an average of 10.9% of their body weight. Participants on the lower initial dose lost about 5.1%, whereas those in the placebo group (diet and exercise alone) lost only 1.6% of their body weight.

The study data also showed that a greater proportion of participants taking Qsymia achieved meaningful weight loss:

47% of those on the higher dose and 19% on the lower dose lost at least 10% of their body weight.
Additionally, 67% of those on the higher dose and 45% on the lower dose lost at least 5.1% of their body weight.

Another interesting finding is that participants taking the higher dose of Qsymia lost at least 5% of their body weight as early as 8 weeks into the study. They also experienced significant improvements in metabolic indicators, such as blood sugar and lipid levels.

In the second study \[2], researchers examined 2,487 participants with a BMI of 27-45, each with at least two additional weight-related health conditions. Participants taking the maximum dose of Qsymia reduced their body weight by an average of 9.8%. Those on the lower initial dose lost about 7.8%, whereas participants in the placebo group, treated with diet and exercise alone, lost only 1.2% of their body weight.

According to the study data, a greater proportion of participants taking Qsymia achieved significant weight loss:

48% of participants on the higher dose and 37% on the lower dose lost at least 10% of their body weight.
Additionally, 70% of participants on the higher dose and 62% on the lower dose lost at least 5.1% of their body weight.

Another interesting point worth noting: Participants in both dosage groups (higher and lower) achieved a weight loss of at least 5% within just 8 weeks of starting the study.

The Multidisciplinary Approach to Obesity Treatment

The most effective method for weight loss through medication is a personalized treatment plan, supported and monitored by a multidisciplinary team of experts.

Various clinical studies \[4,5] conducted in recent years have shown that the most successful approach to weight loss combines individually tailored medications at adjustable dosages, including medication combinations, with medical supervision and ongoing nutritional follow-up by a clinical dietitian within a structured treatment framework. This process significantly improves patient adherence and supports long-term weight maintenance.

The Obesity Treatment Center offers a comprehensive multidisciplinary weight loss program combined with medication-based treatment. This program includes:

Combined Treatment

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To enhance the effectiveness of treatment and achieve maximum results in minimal time, Dr. Raz may combine the medication with additional weight-loss drugs that operate through different mechanisms and adjust dosages based on treatment needs. The Obesity Treatment Center offers innovative and advanced medications at the forefront of weight loss science, and we specialize in creating customized treatment protocols that utilize drug combinations to deliver fast, safe results.

Personal Guidance

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Demonstration and guidance on how to administer the weight-loss medication and how to gradually increase the dosage as needed to achieve maximum results in minimal time.

Diagnosis

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The diagnostic process includes a comprehensive physical examination, measurement of body circumference, weight, metabolic rate, water balance, and body fat and muscle mass percentages. These assessments are performed using advanced technology based on bioelectrical impedance. Each patient undergoes a thorough questionnaire to assess their physical and emotional condition, medical history, underlying health issues, and ongoing medication use, in order to create a fully personalized treatment plan.

Personal Follow-Up

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Dr. Raz maintains personal contact with each patient throughout all treatment stages. Patients attend monthly consultation sessions for tailored treatment adjustments. The Obesity Treatment Center offers 24/7 availability for immediate support. Patients are encouraged to directly contact the center at any time with questions, concerns, or side effects. Immediate responses and guidance are provided without delay. Patients can also monitor their personal treatment progress using a dedicated app. The app provides continuous real-time updates regarding each patient's individual status.

Reducing Side Effects

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Any medication may cause side effects alongside its therapeutic benefits. Many patients have previously tried medication-based weight loss treatments but discontinued due to unmanaged side effects. At the Obesity Treatment Center, we emphasize precise medication dosing tailored to each patient, alongside nutritional adjustments and ongoing monitoring. Clinical experience shows that dynamically adjusting medication doses as needed and ensuring proper drug combinations can prevent or minimize side effects. Additionally, the center provides 24/7 availability to promptly address any side effects in real-time.

Continuity of Care

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As with any medical treatment, weight loss through medication must be carried out consistently as part of a routine. One of the main challenges in this area is patient adherence and their ability to persist with treatment, including medication-based weight loss. Close follow-up at the Obesity Treatment Center, combined with personalized support, side-effect monitoring, and emotional guidance, greatly increases each patient's adherence and significantly reduces dropout rates.

Personally Guided Nutritional Program

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Patients at the center receive ongoing guidance, treatment, and support from a clinical dietitian, with a personalized nutritional plan that addresses all aspects of the patient’s lifestyle, without restricting favorite foods. Moreover, dietary treatment isn't just about a meal plan; at our center, we emphasize not only what to eat but also how to eat. We provide patients with practical behavioral tools to optimally adjust to their medication treatment, helping them reconnect with their natural hunger and fullness signals. This approach keeps the body satisfied and calm throughout the process, enabling significant and lasting weight loss.

Lifestyle Habits

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Many patients come to us frustrated and discouraged from previous failed attempts. Some arrive feeling hopeless, doubting their ability to maintain results, no matter how successful the treatment was. That's exactly where we step in. We focus on providing practical lifestyle tools to help you maintain a healthy weight, even after completing treatment at the clinic. Treatment at the Obesity Medical Center is your first step toward a healthier life and lasting weight management.

טבלת קליקים וויגובי - כל המינונים

Wegovy 0.25mg

Wegovy 0.25mg
מינון	קליק
0.006	1
0.013	2
0.02	3
0.027	4
0.033	5
0.04	6
0.047	7
0.054	8
0.06	9
0.067	10
0.074	11
0.081	12
0.087	13
0.094	14
0.1	15
0.108	16
0.114	17
0.121	18
0.128	19
0.135	20
0.141	21
0.148	22
0.155	23
0.168	24
0.168	25
0.175	26
0.182	27
0.189	28
0.195	29
0.202	30
0.209	31
0.216	32
0.222	33
0.229	34
0.236	35
0.243	36
0.25	37

Wegovy 0.5mg

Wegovy 0.5mg
מינון	קליק
0.0135	1
0.027	2
0.0405	3
0.0541	4
0.0676	5
0.0811	6
0.0946	7
0.1081	8
0.1216	9
0.1351	10
0.1486	11
0.1622	12
0.1757	13
0.1892	14
0.2027	15
0.2162	16
0.2297	17
0.2432	18
0.2568	19
0.2703	20
0.2838	21
0.2973	22
0.3108	23
0.3243	24
0.3378	25
0.3514	26
0.3649	27
0.3784	28
0.391	29
0.405	30
0.418	31
0.432	32
0.445	33
0.459	34
0.472	35
0.486	36
0.5	37

Wegovy 1mg

Wegovy 1mg
מינון	קליק
0.013	1
0.026	2
0.04	3
0.053	4
0.066	5
0.08	6
0.093	7
0.106	8
0.12	9
0.133	10
0.146	11
0.16	12
0.173	13
0.186	14
0.2	15
0.213	16
0.226	17
0.24	18
0.253	19
0.266	20
0.28	21
0.293	22
0.306	23
0.32	24
0.333	25
0.346	26
0.36	27
0.373	28
0.386	29
0.4	30
0.413	31
0.426	32
0.44	33
0.453	34
0.466	35
0.48	36
0.493	37
0.506	38
0.52	39
0.533	40
0.546	41
0.56	42
0.573	43
0.586	44
0.6	45
0.613	46
0.626	47
0.64	48
0.653	49
0.666	50
0.693	51
0.693	52
0.706	53
0.72	54
0.733	55
0.746	56
0.76	57
0.773	58
0.786	59
0.8	60
0.813	61
0.826	62
0.84	63
0.853	64
0.866	65
0.88	66
0.893	67
0.906	68
0.92	69
0.933	70
0.946	71
0.96	72
0.973	73
0.986	74
1	75

Wegovy 1.7mg

Wegovy 1.7mg
מינון	קליק
0.022	1
0.045	2
0.068	3
0.09	4
0.113	5
0.136	6
0.158	7
0.181	8
0.204	9
0.226	10
0.249	11
0.272	12
0.294	13
0.317	14
0.34	15
0.362	16
0.385	17
0.408	18
0.43	19
0.453	20
0.476	21
0.498	22
0.521	23
0.544	24
0.566	25
0.589	26
0.612	27
0.634	28
0.657	29
0.68	30
0.702	31
0.725	32
0.748	33
0.77	34
0.793	35
0.816	36
0.838	37
0.861	38
0.884	39
0.906	40
0.929	41
0.952	42
0.974	43
0.997	44
1.02	45
1.04	46
1.065	47
1.088	48
1.11	49
1.133	50
1.156	51
1.178	52
1.201	53
1.224	54
1.246	55
1.269	56
1.292	57
1.314	58
1.337	59
1.36	60
1.382	61
1.405	62
1.428	63
1.45	64
1.473	65
1.496	66
1.518	67
1.541	68
1.564	69
1.586	70
1.609	71
1.632	72
1.654	73
1.677	74
1.7	75

Wegovy 2.4mg

Wegovy 2.4mg
מינון	קליק
0.032	1
0.064	2
0.096	3
0.128	4
0.16	5
0.192	6
0.224	7
0.256	8
0.288	9
0.32	10
0.352	11
0.384	12
0.416	13
0.448	14
0.48	15
0.512	16
0.544	17
0.576	18
0.608	19
0.64	20
0.672	21
0.704	22
0.736	23
0.768	24
0.8	25
0.832	26
0.864	27
0.896	28
0.928	29
0.96	30
0.992	31
1.024	32
1.056	33
1.088	34
1.12	35
1.152	36
1.184	37
1.216	38
1.248	39
1.28	40
1.312	41
1.344	42
1.376	43
1.408	44
1.44	45
1.472	46
1.504	47
1.536	48
1.568	49
1.6	50
1.632	51
1.664	52
1.696	53
1.728	54
1.76	55
1.792	56
1.824	57
1.856	58
1.888	59
1.92	60
1.952	61
1.984	62
2.016	63
2.048	64
2.08	65
2.112	66
2.144	67
2.176	68
2.208	69
2.24	70
2.272	71
2.304	72
2.336	73
2.368	74
2.4	75

מונג'רו / מאונג'רו טבלת קליקים - מינונים

Mounjaro 2.5mg

מונג’רו 2.5mg
מינון	קליק
0.0417	1
0.0833	2
0.125	3
0.1667	4
0.2083	5
0.25	6
0.2917	7
0.3333	8
0.375	9
0.4167	10
0.5	12
0.625	15
0.75	18
0.8333	20
1	24
1.25	30
1.5	36
1.6667	40
2	48
2.5	60

Mounjaro 5mg

מונג’רו 5mg
קליק	מינון
1	0.0833
2	0.1667
3	0.25
4	0.3333
5	0.4167
6	0.5
7	0.5833
8	0.6667
9	0.75
10	0.8333
12	1
15	1.25
18	1.5
20	1.6667
24	2
30	2.5
36	3
40	3.3333
48	4
60	5

Mounjaro 15mg

מונג’רו 15mg
קליק	מינון
1	0.25
2	0.5
3	0.75
4	1
5	1.25
6	1.5
7	1.75
8	2
9	2.25
10	2.5
12	3
15	3.75
18	4.5
20	5
24	6
30	7.5
36	9
40	10
48	12
60	15

Mounjaro 7.5mg

מונג’רו 7.5mg
קליק	מינון
1	0.125
2	0.25
3	0.375
4	0.5
5	0.625
6	0.75
7	0.875
8	1
9	1.125
10	1.25
12	1.5
15	1.875
18	2.25
20	2.5
24	3
30	3.75
36	4.5
40	5
48	6
60	7.5

Mounjaro 10mg

מונג’רו 10mg
קליק	מינון
1	0.1667
2	0.3333
3	0.5
4	0.6667
5	0.8333
6	1
7	1.1667
8	1.3333
9	1.5
10	1.6667
12	2
15	2.5
18	3
20	3.3333
24	4
30	5
36	6
40	6.6667
48	8
60	10

Mounjaro 12.5mg

מונג’רו 12.5mg
קליק	מינון
1	0.2083
2	0.4167
3	0.625
4	0.8333
5	1.0417
6	1.25
7	1.4583
8	1.6667
9	1.875
10	2.0833
12	2.5
15	3.125
18	3.75
20	4.1667
24	5
30	6.25
36	7.5
40	8.3333
48	10
60	12.5

Frequently Asked Questions (FAQ)

What is the recommended dosage?

When should the medication be taken?

What are the common side effects of Qsymia?

What are the rare side effects of Qsymia?

Who should avoid treatment with Qsymia, and who should exercise caution during treatment?

How much does Qsymia cost, and is it covered by the national healthcare system?

The information on this page does not replace medical consultation or serve as a basis for diagnosis. For detailed information regarding the medication, please refer to the patient information leaflet as approved by the Ministry of Health. For any additional questions, please consult your healthcare provider or pharmacist.